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Updated: Jun 21, 2025
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Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
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In situ fabrication of fully negatively-charged layer-by-layer nanofilms on a living cell surface
Zhuying Zhang1, Jinfeng Zeng1, Michiya Matsusaki1
1Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. m-matsus@chem.eng.osaka-u.ac.jp.
Chemical Communications (Cambridge, England)
|July 9, 2024
Abstract:
Fully negatively-charged (FNC) layer-by-layer nanofilms were successfully assembled on a living cell surface for the first time using only poly(acrylic acid) (PAA) by introducing strain-promoted click chemistry to crosslink PAA layers. The resulting nanofilms retained their negative charges and showed higher adsorption of positively-charged molecules without affecting the cell viability.
