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CD87-targeted BiTE and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas

Yuan Ren1, Xinjie Bao1, Ming Feng1

  • 1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Science China. Life Sciences
|July 10, 2024
PubMed

Insights

CD87 is highly expressed in invasive nonfunctioning pituitary adenomas (iNFPAs). Researchers developed CD87-specific bispecific T-cell engagers (BiTEs) and chimeric antigen receptor-modified T cells (CAR-Ts) that effectively target and reduce iNFPA tumors.

Area of Science:

  • Immunology
  • Oncology
  • Endocrinology

Background:

  • Bispecific T-cell engagers (BiTEs) and chimeric antigen receptor-modified T cells (CAR-Ts) show efficacy in hematological cancers.
  • CD87 is oncogenic and highly expressed in solid tumors.

Purpose of the Study:

  • To evaluate CD87 as a therapeutic target for invasive nonfunctioning pituitary adenomas (iNFPAs).
  • To assess the cytotoxic effects of CD87-specific BiTE and CAR/IL-12 T cells on iNFPAs.

Main Methods:

  • Examined CD87 expression in iNFPA tissues and cells.
  • Generated CD87-specific BiTE and CD87 CAR/IL-12 T cells.
  • Determined cytotoxic effects in vitro and in mouse models.

Main Results:

  • CD87 was highly expressed in iNFPAs but not in normal brain tissue.
  • CD87-specific BiTE and CAR/IL-12 T cells demonstrated antigenic specificity.
  • These engineered T cells reduced iNFPA cell proliferation in vitro and tumor size in vivo.

Conclusions:

  • CD87 is a promising therapeutic target for iNFPAs.
  • Anti-CD87 BiTEs and CD87-specific CAR/IL-12 T cells show potential for iNFPA immunotherapy.
Keywords:
CD87Warburg effectbispecific T cell engagerchimeric antigen receptor T cellsinvasive non-functional pituitary adenomas

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