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Heterogeneity within type II and MODY diabetes
Advances in Experimental Medicine and Biology
|January 1, 1985
Summary
Type II diabetes (NIDDM) and its subset MODY exhibit significant heterogeneity. Differences exist in inheritance, insulin response, obesity association, and vascular disease susceptibility, impacting diagnosis and management.
Area of Science:
- Endocrinology and Metabolism
- Genetics of Diabetes
- Clinical Diabetes Research
Background:
- Type II diabetes (NIDDM) and Maturity-Onset type Diabetes of Young people (MODY) display considerable heterogeneity.
- MODY, an autosomal dominant subset of NIDDM, presents diverse phenotypic expressions and inheritance patterns.
Purpose of the Study:
- To discuss the heterogeneity within Type II diabetes (NIDDM) and MODY.
- To review the definition, phenotypic expression, and varied characteristics of MODY.
- To highlight the implications of this heterogeneity for diagnosis and management.
Main Methods:
- Review of existing literature on NIDDM and MODY.
- Comparison of inheritance patterns, HLA associations, and insulin secretion/action.
- Analysis of obesity's role and vascular disease susceptibility.
Main Results:
- Significant heterogeneity observed in NIDDM and MODY regarding inheritance, insulin response, and tissue sensitivity.
- HLA associations are rare in NIDDM but present in specific groups.
- Obesity influences insulin resistance and uncovers defects; vascular disease susceptibility also varies.
Conclusions:
- Recognizing the heterogeneity of NIDDM and MODY is crucial for accurate diagnosis, management, and prognosis, especially in young patients.
- The classification of diabetes mellitus requires periodic reevaluation to reflect evolving understanding and aid clinicians.