Related Experiment Video

Updated: Jun 19, 2025

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

19.4K

Shaping Microbiota During the First 1000 Days of Life

Anna Samarra1, Eduard Flores1, Manuel Bernabeu1

  • 1Department of Biotechnology, Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Paterna-Valencia, Spain.

Advances in Experimental Medicine and Biology
|July 26, 2024
PubMed

Insights

Understanding the immune system-microbiota relationship from conception through early life is crucial. Dietary strategies like probiotics can positively modulate maternal and infant microbiota for lifelong health benefits.

Area of Science:

  • Immunology
  • Microbiology
  • Developmental Biology

Background:

  • Host-microbe interactions are significantly influenced by immune system responses.
  • The period from conception to early childhood is critical for establishing the immune system-microbiota axis.
  • Understanding this relationship is key for long-term infant health.

Purpose of the Study:

  • To review current evidence on human reproductive microbiota.
  • To examine microbial colonization in early life and its impact on infant development and health.
  • To explore dietary interventions for modulating maternal-neonatal microbiota.

Main Methods:

  • Literature review of existing studies on reproductive and early-life microbiota.
  • Analysis of the role of the immune system in host-microbe interactions during early development.
  • Evaluation of dietary strategies, including probiotics and other 'biotics', for microbiota modulation.

Main Results:

  • Human reproductive tract harbors a distinct microbiota.
  • Early-life microbial colonization significantly influences infant development and health outcomes.
  • Dietary interventions show potential for modulating the maternal-neonatal microbiota.

Conclusions:

  • The maternal-neonatal microbiota plays a critical role in infant health and development.
  • Dietary strategies, particularly probiotics and other 'biotics', offer promising avenues for intervention.
  • Targeted modulation during the early 'window of opportunity' can impact lifelong health.

Keywords:
AntibioticsDietGestationHealthMicrobiotaPrebioticsProbioticsVagina

More Related Videos

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings04:16

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

413
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.5K

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
408
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
298