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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
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Time-restricted eating affects human adipose tissue fat mobilization.
Carolina Zambrano1,2, Elena González-Alvarado1,2, Diego Salmerón2,3,4
1Department of Physiology, Regional Campus of International Excellence, University of Murcia, Murcia, Spain.
Obesity (Silver Spring, Md.)
|July 29, 2024
Summary
Time-restricted eating (TRE) enhances fat mobilization, with early TRE showing greater effects than delayed TRE. Longer fasting durations independently increase fat release, supporting TRE for weight management.
Area of Science:
- Metabolic Health
- Nutritional Science
- Obesity Research
Background:
- Time-restricted eating (TRE) is a dietary strategy involving eating within a specific time window.
- While TRE shows metabolic benefits, its effect on body weight loss requires further investigation.
- Human adipose tissue (AT) cultures offer a model to study lipolysis and fat mobilization.
Purpose of the Study:
- To investigate the impact of early TRE (eTRE) and delayed TRE (dTRE) on fat mobilization.
- To compare the lipolytic effects of eTRE and dTRE using human adipose tissue.
- To explore the relationship between fasting duration and fat mobilization within TRE protocols.
Main Methods:
- Subcutaneous adipose tissue (AT) was obtained from 21 individuals with severe obesity.
- Fat mobilization was assessed by measuring glycerol release from AT cultures.
- Four conditions were tested: control, eTRE, dTRE, and 24-hour fasting.
Main Results:
- Both eTRE and dTRE significantly increased lipolysis (glycerol release) compared to the control.
- eTRE demonstrated higher glycerol mobilization than dTRE, particularly during nighttime/sleep periods.
- Glycerol release increased with longer fasting durations (8, 12, and 16 hours) independently of the eating window.
Conclusions:
- TRE significantly impacts fat mobilization, suggesting potential benefits for weight management.
- eTRE may be more effective than dTRE in promoting fat mobilization.
- Findings support TRE as a strategy for improving metabolic health and facilitating weight loss.
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