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Related Experiment Video

Updated: Jun 17, 2025

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging.

Xi Chen¹, Yifan Wang², Huiqiao Li¹

¹USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

|August 9, 2024

Summary

This summary is machine-generated.

Cold exposure enhances adipose tissue beiging by increasing hyaluronic acid (HA) levels. This suggests HA could be a novel therapeutic target for obesity and metabolic diseases, unlike beta-3 adrenergic receptor agonists.

Keywords:

HAS2 PH20 cold-induced adipose tissue beiging extracellular matrix hyaluronan

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Last Updated: Jun 17, 2025

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Published on: February 13, 2019

Area of Science:

Metabolic research
Adipose tissue biology
Extracellular matrix dynamics

Background:

Adipose tissue beiging, the emergence of beige adipocytes in white adipose tissue, improves metabolism.
Beige adipocytes dissipate energy and secrete adipokines, beneficial for obesity and metabolic diseases.
Cold exposure and beta-3 adrenergic receptor (AR) agonists stimulate beige adipocyte formation via distinct mechanisms.

Purpose of the Study:

Investigate the role of extracellular matrix (ECM) components, specifically hyaluronic acid (HA), in cold-induced adipose tissue beiging.
Compare the effects of cold exposure versus beta-3 AR agonist on HA levels in adipose tissue.
Determine if modulating HA levels impacts adipose tissue beiging.

Main Methods:

Transcriptional analysis of inguinal white adipose tissue (iWAT) following cold exposure.
Measurement of HA levels in iWAT after cold exposure and beta-3 AR agonist (CL316,243) treatment.
Genetic manipulation of HA levels in iWAT using Has2 (to increase HA) and Spam1 (to decrease HA) overexpression in mice.

Main Results:

Cold exposure specifically increased iWAT HA levels, while CL316,243 did not.
Overexpression of Has2 enhanced cold-induced adipose tissue beiging.
Overexpression of Spam1 reduced cold-induced adipose tissue beiging, confirming HA's role.

Conclusions:

Hyaluronic acid (HA) plays a crucial role in promoting adipose tissue beiging, a process specific to cold exposure.
Modulating HA levels offers a potential new therapeutic strategy for metabolic diseases.
Targeting HA may overcome the limitations of beta-3 AR agonists in clinical applications for obesity.