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Updated: Jun 15, 2025
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Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
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A Case of Acute Intoxication from Sublingually Administering a Liquid Inhalation Product Containing a Marijuana
Yuri Iketani1, Seiji Morita, Tomoatsu Tsuji
1Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. e133006g@gmail.com.
The Tokai Journal of Experimental and Clinical Medicine
|August 25, 2024
Summary
Hexahydrocannabiphorol (HHCP) inhalation liquid caused acute poisoning in a young man, leading to convulsions and hallucinations. This case highlights potential health risks associated with HHCP, even after its regulation in Japan.
Area of Science:
- Toxicology
- Pharmacology
Background:
- Hexahydrocannabiphorol (HHCP) is a cannabinoid with limited clinical data.
- HHCP was legally available via mail order in Japan prior to January 2024.
Observation:
- A 20-year-old male presented with dysarthria, vomiting, convulsions, agitation, and visual hallucinations after sublingual HHCP use.
- Initial blood tests revealed acidosis and elevated lactic acid levels.
Findings:
- The patient was diagnosed with acute HHCP poisoning and treated with intravenous fluids.
- Recovery was observed over five days, with improvements in communication and ability to eat.
Implications:
- This case demonstrates that HHCP can cause significant adverse health effects.
- Healthcare providers and the public should remain aware of potential risks from HHCP, despite recent regulatory changes in Japan.
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