CMR to characterize myocardial structure and function in heart failure with preserved left ventricular ejection...

Area of Science:

• Cardiology
• Medical Imaging
• Biophysics

Background:

• Heart failure with preserved ejection fraction (HFpEF) remains a significant clinical challenge with high morbidity and mortality.
• HFpEF is a heterogeneous condition with diverse etiologies, complicating diagnosis and treatment.
• Current therapeutic advancements have not substantially reduced HFpEF burden.

Purpose of the Study:

• To highlight the utility of cardiac magnetic resonance (CMR) as a comprehensive phenotyping tool for HFpEF.
• To explore how advanced CMR techniques can elucidate the underlying pathophysiology of HFpEF.
• To underscore the potential of CMR in guiding personalized therapy for HFpEF.

Main Methods:

• Utilizing multi-parametric cardiac magnetic resonance (CMR) for assessing cardiac morphology and function.
• Employing magnetic resonance spectroscopy (MRS) to investigate cardiac metabolism in HFpEF.
• Integrating exercise CMR with lung water imaging for in-depth pathophysiological analysis.

Main Results:

• CMR enables detailed characterization of cardiac hemodynamics beyond basic morphology and function.
• Magnetic resonance spectroscopy (MRS) provides insights into the metabolic derangements in HFpEF.
• Exercise CMR combined with lung water imaging reveals crucial mechanistic insights into HFpEF.

Conclusions:

• Cardiac magnetic resonance (CMR) serves as a powerful, non-invasive phenotyping tool for HFpEF.
• Advanced CMR techniques offer a comprehensive understanding of HFpEF's complex pathophysiology.
• CMR-based phenotyping facilitates targeted diagnostics, personalized therapy, and improved prevention strategies for HFpEF.