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Validation of advanced hybrid SPECT/CT system using dynamic anthropomorphic cardiac phantom
Elad Gelbart1, Alexander Krakovich2, Yigal Sherm3
1Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Annals of Nuclear Medicine
|August 29, 2024
Summary
A new cardiac phantom validated the StarGuide hybrid SPECT/CT system for myocardial blood flow (MBF) assessment. The system demonstrated high accuracy and precision in measuring MBF, confirming its reliability for dynamic SPECT imaging.
Area of Science:
- Nuclear Medicine
- Cardiovascular Imaging
- Medical Physics
Background:
- Myocardial blood flow (MBF) assessment is crucial for diagnosing and prognosticating cardiac conditions.
- Dynamic single-photon emission computed tomography (SPECT) requires robust validation for accurate MBF quantification.
- A novel cardiac phantom was previously developed for dynamic SPECT validation.
Purpose of the Study:
- To validate the performance of a new hybrid SPECT/CT system (StarGuide™) with cadmium zinc telluride (CZT) technology for dynamic MBF assessment.
- To compare the MBF measurements from the StarGuide system against a validated cardiac phantom.
Main Methods:
- A recently developed cardiac phantom, using technetium-99m, generated physiological time activity curves (TACs) for myocardial blood flow (MBF) and uptake rate (K1) calculations.
- The StarGuide hybrid SPECT/CT system acquired and processed TACs, which were then compared to the phantom's reference TACs and mathematical model.
- Fifteen experiments with varying radiotracer doses were conducted to assess MBF across a range of physiological values.
Main Results:
- The StarGuide system's TACs showed significant correlation with the phantom's reference TACs for both the left ventricle (r=0.94) and myocardium (r=0.89) (p<0.001).
- The mean absolute difference in MBF between the StarGuide system and the phantom was 0.14 ± 0.16 ml/min/g, with an average relative difference of 13.2 ± 8.1%.
- The coefficient of variance for MBF measurements was ≤11%, and regional uptake rate differences were within 5% of global values.
Conclusions:
- The newly developed dynamic cardiac phantom successfully validated the dynamic hybrid SPECT/CT CZT-based StarGuide™ system.
- The StarGuide system demonstrated high accuracy and precision in assessing myocardial blood flow.
- The StarGuide system is reliable for performing dynamic SPECT acquisitions across a wide spectrum of myocardial perfusion rates.
