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An Aptamer Glue Enables Hyperefficient Targeted Membrane Protein Degradation

Guo-Rong Zhang1, Chi Zhang1, Ting Fu2

  • 1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China.

JACS Au
|August 30, 2024
PubMed
Summary

This study introduces a novel targeted membrane protein degradation system (TMPDS) for efficient removal of harmful proteins. The new system overcomes limitations of current methods, offering therapeutic potential and aiding biological pathway studies.

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