Polysaccharide-Based Composite Systems in Bone Tissue Engineering: A Review

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Materials Science

Background:

• Growing demand for biomaterials in bone regenerative medicine.
• Bone tissue engineering (BTE) seeks innovative strategies for bone repair.
• Polysaccharides offer biocompatibility, biodegradability, and bioactivity for BTE scaffolds.

Purpose of the Study:

• To comprehensively analyze composite systems based on polysaccharides for bone tissue engineering.
• To highlight synthesis, properties, and applications of these polysaccharide-bioceramic composites.
• To review new trends in biomaterial modification and functionalization for enhanced performance.

Main Methods:

• Review of existing literature on polysaccharide-based composite systems for BTE.
• Analysis of synthesis methods, material properties, and application data.
• Critical evaluation of mechanical properties, biocompatibility, and osteoconductivity.

Main Results:

• Polysaccharide-calcium phosphate (CaP) ceramic composites demonstrate potential for BTE.
• These composites support osteointegration and stimulate new apatite layer formation.
• Analysis covers recent manufacturing methods and functionalization strategies.

Conclusions:

• Polysaccharide-bioceramic composites are promising for bone and cartilage regeneration.
• Further research into material modification and functionalization can optimize outcomes.
• These advanced biomaterials hold significant potential for clinical applications in tissue repair.