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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible Light/Copper Catalysis-Enabled Arylation and Alkenylation of Phosphorothioates via Site-Selective C-H
Guoju Guo1, Jie Ma1, Yuzhen Dong1
1College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Abstract:
An efficient visible light/copper-enabled arylation and alkenylation of phosphorothioates with thianthrenium salts via a C(sp2)-S cross-coupling reaction have been demonstrated. This strategy uses aryl/alkenyl thianthrenium salts as new electrophilic reagents, which can be easily prepared by the site-selective C-H thianthrenation of arenes/alkenes with high regioselectivity. Mechanistic studies revealed a crucial role of the in situ formed copper-sulfur complex, which undergoes a facile SET process with the thianthrenium salts under visible light conditions, thereby successfully achieving the desired cross-coupling reactivity.
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