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NSAID-induced Gastric Ulcer Disease: A Deleterious Connection
Hamza Islam1, Areeba Siddiqui2, Rabia Islam1
1Department of Internal Medicine, Punjab Medical College, 38000 Faisalabad, Pakistan.
Discovery Medicine
|September 26, 2024
Summary
Non-steroidal anti-inflammatory drug (NSAID) use is a major risk factor for peptic ulcers. This review covers NSAID-induced ulcers, focusing on prevention and management strategies for patients.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Non-steroidal anti-inflammatory drug (NSAID) use is a significant public health concern linked to peptic ulcer pathogenesis.
- Chronic NSAID use is a primary risk factor for peptic ulcers, particularly in patients with comorbidities or on anticoagulant therapy.
Purpose of the Study:
- To review risk factors, pathogenesis, clinical presentation, diagnosis, prevention, and treatment of NSAID-induced peptic ulcers.
- To highlight effective strategies for managing and preventing peptic ulcers in NSAID users.
Main Methods:
- Comprehensive literature review of studies on NSAID-induced peptic ulcers.
- Analysis of diagnostic tests and alternative medications for NSAID toxicity.
Main Results:
- NSAID usage is strongly associated with peptic mucosal erosion.
- Selective cyclooxygenase-2 (COX-2) inhibitors and lowest effective NSAID dosages are recommended for prevention.
Conclusions:
- Effective prevention and management of NSAID-induced ulcers are crucial.
- Utilizing COX-2 inhibitors or minimizing NSAID dosage can mitigate ulcer risk in vulnerable populations.
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