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Updated: Jun 11, 2025
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
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Metabolomics: Implication in cardiovascular research and diseases.
Amir Ajoolabady1, Domenico Pratico2, Warwick B Dunn3,4
1Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Summary
Metabolic disorders significantly impact cardiovascular health, leading to cardiovascular diseases (CVDs). Metabolomics offers a comprehensive approach to understand CVD pathogenesis, diagnosis, and management.
Area of Science:
- Biochemistry
- Cardiology
- Genomics
Background:
- Cellular metabolism is vital for organismal health and its disruption is linked to cardiovascular diseases (CVDs).
- Comorbidities can worsen cardiovascular metabolism, creating a detrimental cycle with CVD.
- Metabolic alterations play a key role in the development and progression of CVD.
Purpose of the Study:
- To provide a comprehensive overview of metabolomics applications in cardiovascular diseases (CVDs).
- To explore the role of metabolomics in understanding CVD pathogenesis, diagnosis, prognosis, and management.
- To discuss future perspectives and limitations of metabolomics in CVD research.
Main Methods:
- Review of experimental and clinical studies utilizing metabolomics in cardiovascular disease research.
- Analysis of metabolite profiles and metabolic pathways relevant to CVD.
- Synthesis of current knowledge on metabolomics applications in CVD.
Main Results:
- Metabolomics enables a detailed assessment of metabolites and metabolic architecture.
- Metabolite profiles and pathways enhance understanding of CVD pathophysiology and genomic landscape.
- Metabolomics has diverse applications across the spectrum of CVD, from pathogenesis to management.
Conclusions:
- Metabolomics is an essential tool for advancing our understanding of cardiovascular diseases (CVDs).
- Its applications span from early diagnosis to personalized management strategies for CVD.
- Further research is needed to fully harness the potential of metabolomics in combating CVD.
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