Related Experiment Video
Updated: Jun 11, 2025
06:15
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
49.7K
Prematurity-associated lung disease: is it asthma?
Tiffany K Bradshaw1, Elizabeth F Smith1,2, Rhea C Urs1,2
1Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Australia.
ERJ Open Research
|October 7, 2024
Summary
Wheezing in very preterm infants is not always asthma. More research is essential to understand the causes of lung disease in these infants and identify optimal treatments.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Respiratory Health
Background:
- Infants born very preterm often experience respiratory issues.
- Wheezing is a common symptom, but its cause in this population is not fully understood.
- Distinguishing between different causes of wheezing is crucial for effective management.
Purpose of the Study:
- To investigate the diverse causes of wheezing in infants born very preterm.
- To differentiate wheezing phenotypes beyond typical asthma.
- To inform targeted therapeutic strategies for prematurity-associated lung disease.
Main Methods:
- Longitudinal cohort study of very preterm infants.
- Clinical assessment of respiratory symptoms, including wheeze.
- Diagnostic evaluations to identify underlying respiratory conditions.
- Analysis of factors associated with wheezing phenotypes.
Main Results:
- Wheezing in very preterm infants presents with varied etiologies, not exclusively asthma.
- Specific clinical characteristics and risk factors are associated with different wheezing patterns.
- A significant proportion of wheezing cases may stem from non-asthmatic conditions.
Conclusions:
- The common assumption that all wheeze in very preterm infants is asthma is inaccurate.
- Understanding the specific causes of lung disease in this population is critical.
- Further research is required to develop tailored treatments for prematurity-associated respiratory conditions.
Related Concept Videos
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:20Asthma: Pathogenesis and Management
363
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
363
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:05Breathing
58.9K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
58.9K
01:24Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
01:17Pulmonary Cycle: Exhalation
1.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K