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Related Experiment Video

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The CellFX Percutaneous Electrode System for Nanosecond Pulsed Field Ablation.

Richard Nuccitelli1, Jeffrey Litt1, Kevin Moss1

  • 1Pulse Biosciences, Inc., Hayward, California, USA.

Bioelectricity
|October 7, 2024
PubMed
Summary

The CellFX system safely and effectively ablated liver, kidney, and muscle tissues using nanosecond pulsed field ablation (nsPFA). This novel nsPFA technology demonstrated no thermal damage, highlighting its potential for soft tissue ablation.

Keywords:
CellFXNanosecond pulsed field ablationablationapoptosisnanosecond electric pulsesnsPFApercutaneous electroderegulated cell death

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Area of Science:

  • Biomedical Engineering
  • Surgical Technology
  • Electrophysiology

Background:

  • Pulsed field ablation (PFA) is an emerging modality for tissue ablation.
  • Nanosecond pulsed field ablation (nsPFA) offers a novel approach to energy delivery for ablation.
  • Evaluating the safety and efficacy of new ablation technologies is crucial for clinical translation.

Purpose of the Study:

  • To assess the safety and performance of the CellFX Percutaneous Electrode for nsPFA in soft tissues.
  • To compare the histological effects of nsPFA with radiofrequency (RF) ablation.
  • To evaluate systemic tolerability of nsPFA treatment.

Main Methods:

  • Porcine liver, kidney, and skeletal muscle were treated with nsPFA at supratherapeutic levels.
  • Histological analysis of ablation zones was performed at 0 and 2 days post-treatment.
  • Ablation dimensions were measured, and systemic effects were monitored via urinalysis and serum chemistry.

Main Results:

  • The CellFX system successfully induced ablation and necrosis in all tested tissues.
  • No thermal effects or collagen degeneration were observed at nsPFA treatment sites.
  • No clinically significant systemic changes were detected, indicating good tolerability.

Conclusions:

  • The CellFX system demonstrates promising safety and performance for nsPFA in soft tissues.
  • nsPFA shows a favorable non-thermal ablation profile compared to RF ablation.
  • Further investigation is warranted for clinical applications of nsPFA technology.