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Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Related Experiment Video

Updated: Jun 11, 2025

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
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Published on: January 12, 2017

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Cancer-Related Lymphedema and Psychological Distress.

Kelsey Lau1, Shivali Patel2,3, Katie Rogers4

  • 1Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.

Current Psychiatry Reports
|October 8, 2024
PubMed
Summary

Cancer-related lymphedema (CRL) causes significant psychological distress due to body image, sleep, and social changes. Effective management involves non-pharmacologic therapies like exercise and psychotherapy, alongside evidence-based CRL treatments.

Keywords:
AnxietyCancerDepressionDistressFunctionLymphedemaPsychosocialQuality of life

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Area of Science:

  • Oncology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Cancer-related lymphedema (CRL) significantly impacts patients' psychological well-being.
  • Patients with CRL are at increased risk for psychological distress, affecting quality of life.

Purpose of the Study:

  • To review factors contributing to psychological distress in CRL patients.
  • To discuss treatment considerations for managing distress in CRL.

Main Methods:

  • Literature review focusing on CRL and psychological distress.
  • Analysis of contributing factors and treatment modalities.

Main Results:

  • Distress in CRL is linked to body image, sleep, sexuality, function, and social interaction changes.
  • Limited data exists on psychopharmacology for CRL; exercise shows promise for depression and anxiety.
  • Multidisciplinary awareness of CRL is crucial for effective distress management.

Conclusions:

  • Managing CRL distress requires a holistic approach, considering psychotropic side effects.
  • Non-pharmacologic interventions, including psychotherapy and exercise, are vital.
  • Ensuring evidence-based CRL treatment is essential for patient well-being.