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Related Experiment Video

Updated: May 5, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

Cerebral Oxygen Monitoring in Extremely Low-Birth-Weight Infants Using Time-Domain Near-Infrared Spectroscopy in

Hiroaki Suzuki¹, Toshiyuki Imanishi², Norihiro Suzuki³

¹Central Research Laboratory, Hamamatsu Photonics K.K, Shizuoka, Japan. hiro-su@crl.hpk.co.jp.

Advances in Experimental Medicine and Biology

|October 14, 2024

Summary

Time-domain near-infrared spectroscopy (TD-NIRS) monitored extremely low-birth-weight infants (ELBWIs). TD-NIRS detected optical signals and measured changes in hemoglobin and oxygen saturation, aiding brain monitoring for ELBWIs.

Keywords:

Deep brain ELBWI NICU TD-NIRS Transmittance mode

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Last Updated: May 5, 2026

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Published on: November 19, 2020

Area of Science:

Neonatal intensive care
Medical technology
Neuroscience

Background:

Neonatal intensive care advances have increased survival for extremely low-birth-weight infants (ELBWIs).
However, long-term neurological sequelae remain a significant challenge for survivors.
Improved methods for monitoring ELBWIs in the neonatal intensive care unit (NICU) are crucial.

Purpose of the Study:

To evaluate the utility of time-domain near-infrared spectroscopy (TD-NIRS) for deep brain monitoring in ELBWIs.
To assess the feasibility of using TD-NIRS in a clinical NICU setting.
To identify potential correlations between TD-NIRS parameters and infant development.

Main Methods:

Utilized a TD-NIRS system in transmittance mode to measure the heads of three ELBWIs weekly.
Collected optical signal data, including total hemoglobin concentration, tissue oxygen saturation, and reduced scattering coefficient.
Analyzed data in relation to postmenstrual age and time after birth.

Main Results:

Optical signals transmitted through the infant heads were successfully detected in all subjects.
Total hemoglobin concentration and tissue oxygen saturation showed a decrease in the first month post-birth.
The reduced scattering coefficient did not show a significant correlation with postmenstrual age.

Conclusions:

TD-NIRS is a feasible technique for deep brain monitoring in ELBWIs within the NICU.
Observed changes in hemoglobin and oxygen saturation suggest potential for tracking cerebral circulation.
TD-NIRS may offer a valuable tool for clinical assessment and management of cerebral hemodynamics in premature infants.