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Related Experiment Video

Updated: Jun 10, 2025

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
10:22

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

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Fabrication of Tuneable Tissue-Mimicking Phantom for Optical Methods.

Tong Li1, Aldo Di Costanzo Mata2, Alexander Kalyanov2

  • 1Biomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zürich, Switzerland. tong.li@usz.ch.

Advances in Experimental Medicine and Biology
|October 14, 2024
PubMed
Summary

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This study introduces a novel dynamic phantom for near-infrared imaging devices. The system accurately mimics complex human tissue structures and optical properties, enabling better validation of optical technologies.

Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology
  • Optical Phantoms

Background:

  • Tissue-mimicking optical phantoms are crucial for calibrating near-infrared spectroscopy (NIRS) and tomography (NIROT) devices.
  • Existing phantoms often lack the complex structures and dynamic optical properties of human tissues.

Purpose of the Study:

  • To design, fabricate, and characterize a novel phantom system for testing near-infrared imaging devices.
  • To create a phantom with arbitrary internal shapes and continuously variable optical properties.

Main Methods:

  • A dynamic phantom platform was developed using silicone with embedded polyvinyl alcohol (PVA) structures.
  • Internal hollow shapes were created by dissolving PVA, and optical properties were adjusted by injecting liquid solutions.
Keywords:
Dynamic phantomsNear-infrared spectroscopyNear-infrared tomographyOptical devicesOptical phantoms

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  • The phantom was evaluated using frequency domain near-infrared spectroscopy (FD NIRS) and time domain near-infrared optical tomography (TD NIROT).

    • Main Results:

    • A dynamic phantom system with a complex internal structure and adjustable optical properties was successfully created.
    • FD NIRS detected changes in light intensity within the phantom.
    • TD NIROT accurately reconstructed the internal structure of the phantom.

    Conclusions:

    • The developed phantom system effectively mimics dynamic human tissue properties.
    • This novel phantom is a valuable tool for validating and improving near-infrared imaging technologies.