Nickel-Catalyzed Cross-Electrophile Vinylation of α-Chloro Phosphonates
Liang Zou1, Huimin Yang1, Tian Xie1
1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
Abstract:
Herein, we report a general and efficient Ni-catalyzed reductive cross-coupling reaction of substituted vinyl bromides and α-chloro phosphonates to access a set of α-vinyl phosphonates using zinc as the terminal reductant. This reaction exhibits broad substrate adaptability and good functional group tolerance, which allows to afford diverse compounds including structurally complex motifs from natural products and drugs. Furthermore, the practicality was certificated through the gram-scale and transformation experiments. The preliminary mechanistic investigations support a radical chain process. The potential to realize enantiomeric control makes it more valuable for further exploration.
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