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Does Injectable Platelet-Rich Fibrin Combined With Autogenous Demineralized Dentine Enhance Alveolar Ridge
Odai Amer1, Nesma Shemais1, Karim Fawzy El-Sayed1,2,3
1Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Clinical Oral Implants Research
|October 21, 2024
Summary
Autogenous demineralized dentin graft (ADDG) with injectable platelet-rich fibrin (i-PRF) showed similar alveolar ridge preservation outcomes to ADDG alone. However, ADDG + i-PRF reduced postoperative pain and preserved keratinized tissue.
Area of Science:
- Dentistry
- Oral Surgery
- Regenerative Medicine
Background:
- Alveolar ridge preservation (ARP) is crucial for maintaining bone volume after tooth extraction, especially in the aesthetic zone.
- Autogenous demineralized dentin graft (ADDG) is a viable option for ARP.
- Injectable platelet-rich fibrin (i-PRF) is known for its regenerative properties.
Purpose of the Study:
- To evaluate the efficacy of ADDG combined with i-PRF for ARP in the maxillary aesthetic zone.
- To compare the outcomes of ADDG + i-PRF versus ADDG alone in terms of dimensional changes, tissue preservation, and patient-reported results.
Main Methods:
- A randomized controlled trial involving 22 maxillary non-molar teeth indicated for extraction.
- Grafts were prepared from extracted teeth (ADDG) and placed with or without i-PRF.
- Ridge dimensions, keratinized tissue width, patient satisfaction, pain, and chair time were assessed.
- Histomorphometric analysis of bone biopsies was performed at 6 months.
Main Results:
- No significant differences in ridge width or height reduction between ADDG + i-PRF and ADDG groups.
- ADDG + i-PRF showed significantly less reduction in keratinized tissue width (p=0.008).
- Postoperative pain scores were significantly lower in the ADDG + i-PRF group (p=0.012).
- Patient satisfaction and chair time were comparable between groups.
- Histomorphometry revealed no significant differences in newly formed bone, soft tissue, or graft particles.
Conclusions:
- Both ADDG and ADDG + i-PRF are effective for ARP in the maxillary aesthetic zone, yielding similar clinical and histomorphometric results.
- The addition of i-PRF to ADDG may offer benefits by preserving keratinized tissue and reducing postoperative pain.
- Patient satisfaction is high with both treatment modalities.
