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Lewy bodies dementia and Primary progressive aphasias: current diagnostic criteria

Juan Ollari1, Waleska Berrios2, Romina Blanco3

  • 1Médico neurólogo. Docente Autorizado de Neurología, Facultad de Medicina, Universidad de Buenos Aires (UBA). Jefe del Centro de Neurología Cognitiva (CeNeCo), Servicio de Neurología, Hospital Británico de Buenos Aires.. edithlabos@gmail.com.

Vertex (Buenos Aires, Argentina)
|October 21, 2024
PubMed

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Summary
This summary is machine-generated.

This review examines diagnostic criteria for Lewy body dementia, the second most common neurodegenerative dementia. It also covers primary progressive aphasias, which impact language and can mimic atypical Alzheimer's disease.

Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Context:

  • Neurodegenerative diseases present a spectrum from preclinical stages to severe dementia.
  • Lewy body dementia (LBD) is the second leading cause of neurodegenerative dementia in individuals over 65.
  • Primary progressive aphasias (PPAs) initially affect linguistic functions but evolve into complex syndromes.

Purpose:

  • To review current diagnostic criteria for Lewy body dementia.
  • To discuss primary progressive aphasias and their complex clinical presentation.
  • To differentiate these conditions from atypical Alzheimer's disease and mixed pathologies.

Summary:

  • The review focuses on diagnostic criteria for Lewy body dementia, a common cause of dementia in older adults.
  • It details primary progressive aphasias, characterized by early language deficits progressing to cognitive, behavioral, and motor impairments.
Keywords:
dementiafrontotemporal lobar degenerationprimary progressive aphasiataupathiesproteinopathiesTDP-43 and FUS

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  • These conditions can also manifest as atypical Alzheimer's disease or mixed dementia.

    • Impact:

    • Improved diagnostic accuracy for Lewy body dementia and primary progressive aphasias.
    • Enhanced understanding of the differential diagnosis between LBD, PPAs, and Alzheimer's disease.
    • Facilitates earlier and more precise clinical management of these neurodegenerative conditions.