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Updated: Jun 9, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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Supporting Infants with Multicystic Dysplastic Kidney Disease: A Comprehensive Approach

Haley M Baker, Amy J Jnah

    Neonatal Network : NN
    |October 21, 2024
    PubMed

    Insights

    Multicystic dysplastic kidney (MCDK) is a congenital kidney disease. This case highlights diagnosis and management, emphasizing surveillance for better neonatal outcomes.

    Area of Science:

    • Pediatric Nephrology
    • Congenital Abnormalities
    • Renal Development

    Background:

    • Multicystic dysplastic kidney (MCDK) is a congenital renal malformation.
    • Characterized by non-communicative cysts that impede kidney development and function.
    • Outcomes vary based on laterality and severity, with unilateral cases often having better prognoses.

    Purpose of the Study:

    • To present a case of unilateral MCDK and contralateral renal dysplasia.
    • To review the epidemiology, epigenetics, and pathophysiology of MCDK.
    • To outline surveillance strategies for healthcare providers.

    Main Methods:

    • Case report of a patient diagnosed with left-sided MCDK and right-sided renal dysplasia.
    • Literature review encompassing epidemiology, epigenetics, and pathophysiology.
    • Discussion of prenatal, intrapartum, and postnatal surveillance methods.

    Main Results:

    • The case illustrates diagnosis at a nontertiary center.
    • Review provides comprehensive insights into MCDK etiology and progression.
    • Surveillance methods are detailed to guide clinical practice.

    Conclusions:

    • Early recognition and appropriate management are crucial for MCDK patients.
    • Collaboration between neonatal care, nephrology, and urology specialists improves outcomes.
    • Understanding disease mechanisms aids in developing targeted interventions.

    Keywords:
    GI/GUMCDKchronic kidney diseasecongenital anomalies of the kidney and urinary tractcontralateral hypertrophyend-stage renal diseasemulticystic dysplastic kidneyneonatalpretermrenal dysfunction

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