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Updated: Jun 9, 2025

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NHPI-Catalyzed Electro-Oxidation of Alcohols to Aldehydes and Ketones
Jianyou Zhao1, Chengling Deng1, Lanlan Zhang1
1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Abstract:
A practical and recyclable electro-oxidation of alcohols to aldehydes and ketones by using N-hydroxyphthalimide (NHPI) as the catalyst is presented. Through an undivided pool, under constant current conditions, various alcohols can be oxidized to the corresponding aldehydes or ketones in a high yield. Compared with previous methods, this system has the following characteristics: (1) the catalyst, electrode, electrolyte, and solvent (mainly water) are recyclable; (2) it has many advantages such as mild reaction conditions, easy operation, and good tolerance of functional groups; and (3) it can be smoothly scaled up to kilogram-scale production.
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