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Two-hour lactose breath hydrogen test.

A Abramowitz, E Granot, I Tamir

    Journal of Pediatric Gastroenterology and Nutrition
    |January 1, 1986
    PubMed
    Summary
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    The lactose breath hydrogen test (LBHT) can reliably detect lactose malabsorption using only two air samples, at 0 and 120 minutes. This simplifies the test, reducing the need for multiple hydrogen (H2) measurements.

    Area of Science:

    • Gastroenterology
    • Diagnostic Medicine
    • Biochemistry

    Background:

    • The lactose breath hydrogen test (LBHT) is commonly used to diagnose lactose malabsorption.
    • Current LBHT protocols require serial expired air samplings and multiple hydrogen (H2) determinations.
    • The necessity of multiple sampling points in LBHT has been questioned.

    Purpose of the Study:

    • To evaluate whether multiple expired air samplings are necessary for accurate detection of lactose malabsorption.
    • To determine if a simplified LBHT protocol can reliably identify lactose malabsorption.

    Main Methods:

    • A retrospective analysis of 132 consecutive LBHTs was performed.
    • Expired air samples were collected at 0, 30, 60, 90, 120, 150, and 180 minutes post-lactose ingestion.

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  • Hydrogen (H2) concentrations in expired air were measured.

    • Main Results:

    • Fifty-five of the 132 LBHTs were positive for lactose malabsorption.
    • All positive tests showed elevated breath H2 concentrations at 120 minutes.
    • Examining only the 0 and 120-minute samples was sufficient to diagnose all cases of lactose malabsorption, with a low false-positive rate (5.2%).

    Conclusions:

    • The lactose breath hydrogen test can be reliably performed using only expired air samples collected at 0 and 120 minutes.
    • This simplified approach reduces the need for serial sampling and multiple H2 determinations.
    • The findings suggest LBHT can be streamlined, similar to single-sample tests for other malabsorption conditions.