A Multi-Channel Urine Sensing Detection System Based on Creatinine, Uric Acid, and pH.

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Nanomaterials Science

Background:

• Urine analysis is vital for diagnosing various health conditions.
• Creatinine, uric acid, and urine pH are key biomarkers linked to hypertension, cardiovascular, and kidney diseases.
• Current detection methods can be complex and inaccessible for widespread screening.

Purpose of the Study:

• To develop an integrated multi-channel electrochemical sensing system for simultaneous detection of urine creatinine, uric acid, and pH.
• To create a smartphone-interactive platform for intelligent, real-time, and off-body analysis.
• To enhance early disease risk assessment through accessible point-of-care diagnostics.

Main Methods:

• Design of multi-channel selective electrodes for creatinine, uric acid, and pH.
• Integration of electrochemical analysis, microelectronic design, and nanomaterials.
• Development of a smartphone-based WeChat mini-program for data display and interaction.

Main Results:

• Selective electrodes demonstrated detection ranges: 10 nM–100 μM (creatinine), 100 μM–500 μM (uric acid), and pH 4–9.
• Interference experiments confirmed sensor specificity.
• Successful integration with a smart sensing system and wireless smartphone interface for real-time detection.

Conclusions:

• The developed system offers a novel approach for intelligent and real-time urine biomarker detection.
• This technology has the potential for application in primary healthcare and home-based health monitoring.
• The system facilitates convenient and accessible screening for conditions associated with altered creatinine, uric acid, and pH levels.