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Area of Science:

  • Supramolecular chemistry
  • Polymer science
  • Nanomaterials engineering

Background:

  • Nucleobase-containing polymers offer unique self-assembly properties.
  • Controlling supramolecular morphology is crucial for advanced material design.
  • pH-induced transitions in self-assembled systems are of significant interest.

Purpose of the Study:

  • To synthesize and characterize supramolecular coassembled nucleobase copolymers.
  • To investigate the effect of pH changes on copolymer morphology.
  • To elucidate the role of intermolecular interactions in dictating assembly behavior.

Main Methods:

  • Reversible Addition-Fragmentation chain Transfer (RAFT) polymerization for copolymer synthesis.
  • Preparation of coassemblies in aqueous buffers at pH 7.4 and 10.
  • Morphological analysis of coassemblies.
  • Isothermal titration calorimetry (ITC) to study binding interactions.

Main Results:

  • Spherical morphologies formed at physiological pH (7.4).
  • Increased pH (10) induced irreversible, anisotropic supramolecular architectures.
  • Hydrogen bonds dominated assembly at pH 7.4, while hydrophobic interactions prevailed at pH 10.
  • Morphology transitions were directly linked to the dominant interaction type.

Conclusions:

  • Supramolecular interactions (H-bonds vs. hydrophobic) significantly influence nucleobase copolymer morphology.
  • pH-triggered changes in interaction dominance lead to distinct supramolecular architectures.
  • Findings provide insights for designing responsive nanomaterials with tunable properties.