Advances in Electrospun Poly(ε-caprolactone)-Based Nanofibrous Scaffolds for Tissue Engineering

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Nanotechnology

Background:

• Tissue engineering utilizes scaffolds for cell growth and tissue restoration.
• Poly(ε-caprolactone) (PCL) is a strong, biodegradable biopolymer used in scaffolds.
• PCL alone has limitations in cell adherence and wettability.

Purpose of the Study:

• Review fabrication methods for electrospun PCL-based nanofibrous scaffolds.
• Explore applications of PCL-based scaffolds in tissue engineering.
• Highlight strategies to enhance scaffold properties.

Main Methods:

• Electrospinning of PCL-based nanofibers (single, blended, core-shell, multi-layered).
• Tuning nanofiber properties: diameter, composition, mechanical strength, drug-loading.
• Employing scaffold layering, surface modification, and coating techniques.

Main Results:

• Electrospun PCL scaffolds offer tunable properties for tissue engineering.
• Blending PCL with other biomaterials enhances scaffold characteristics.
• Structural modifications and surface treatments improve wettability, mechanical strength, and biocompatibility.

Conclusions:

• Electrospun PCL-based scaffolds are promising for tissue engineering applications.
• Fabrication techniques and modifications can optimize scaffold performance.
• Further research can advance PCL scaffold utilization in regenerative medicine.