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Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
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Machine learning-optimized non-invasive brain stimulation and treatment response classification for major depression.
Alejandro Albizu1,2, Aprinda Indahlastari1,3, Paulo Suen4
1Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, USA.
Bioelectronic Medicine
|October 30, 2024
Summary
Personalized transcranial direct current stimulation (tDCS) dosing, using individual brain anatomy, significantly improves treatment response likelihood for major depressive disorder (MDD). This precision approach optimizes tDCS efficacy for better patient outcomes.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Engineering
Background:
- Transcranial direct current stimulation (tDCS) shows promise for treating major depressive disorder (MDD).
- Clinical efficacy of tDCS varies due to individual anatomical differences affecting electric field distribution.
- Personalized tDCS dosage may optimize treatment outcomes in MDD.
Purpose of the Study:
- To address tDCS dosing variability in MDD.
- To develop individualized neuroimaging-derived computational models for tDCS.
- To classify treatment response and identify key stimulation features for personalized dosing.
Main Methods:
- Utilized a subsample of 16 active-tDCS participants from the ELECT clinical trial.
- Generated individualized computational models of tDCS current based on neuroimaging data.
- Employed machine learning algorithms to classify treatment responders and compute precision doses.
Main Results:
- tDCS demonstrated superiority over placebo in the ELECT trial.
- The developed algorithm achieved over 90% accuracy in classifying treatment responders.
- Computed precision doses increased response likelihood to 99.981% and reduced dosing variability by 91.9%.
Conclusions:
- The precision-dosing method optimizes the statistical likelihood of tDCS treatment response in MDD.
- This approach offers a pathway to enhance functional gains by accounting for individual anatomical variations.
- Findings support the application of personalized tDCS dosing in psychiatric treatment.
