Hypervalent iodine catalysis enabled iterative multi-fluorination: not just a simple alternative for the
Cheng-Lin Ding1, Hechen Li1, Yi Zhong1
1Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China. Linyuqi@fzu.edu.cn.
Abstract:
Unlike the well-established fluoroalkylation, the direct incorporation of multiple fluorine atoms into small molecules via iterative fluorinations has been much less investigated. Herein, we report a hypervalent iodine catalytically selective multi-fluorination in which the fluorination degree is controlled by the delicate balance between the HF/amine ratios. The pros and cons of hypervalent iodine catalysis and the previously established electrochemical approach in the iterative multi-fluorinations are also provided.
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