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Updated: Jun 8, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
History, Advances, and Challenges of Sickle Cell Disease Treatment
Ritika Walia1, Kleber Y Fertrin2, Daniel E Sabath3
1Hematopathology Division, Department of Laboratory Medicine and Pathology, University of Washington, 1144 Eastlake Avenue East, LG-200, Seattle, WA 98109, USA.
Abstract:
Sickle cell disease (SCD) is marked by red blood cells that deform into a sickle shape, causing severe health complications. Historic neglect and slow therapeutic progress have left many, especially African descendants, vulnerable. Recent treatment strides include novel drugs and gene therapy, promising improved management. Nonetheless, challenges persist with treatment adoption because of cost, adverse effects, and accessibility. Advancements hold hope for enhanced life quality and longevity for SCD patients.
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