Patiens with psoriasis and mild to moderate skin disease can be treated with topical agents. This review finds that the most effective topical treatment is calcipotriol and betamethasone combination formulations. Pure topical corticosteroids continue to have a role in the treatment of psoriasis, as they are available in many strengths and formulations that facilitate ease of use. In addition, the price is often lower than for the combination formulations. Topical calcineurin inhibitors can treat facial and intertriginous psoriasis to reduce the risk of skin atrophy.