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Updated: Jun 6, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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Deubiquitinase OTUD7B Regulates Cell Proliferation in Breast Cancer

Xiu Zhang1, Peng Zhang1, Xiang Chen1

  • 1Central Laboratory, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China.

Clinical Breast Cancer
|November 24, 2024
PubMed
Summary

The deubiquitylase OTUD7B acts as a tumor suppressor in breast cancer, inhibiting cell growth and invasion by disrupting the RAS signaling pathway. Its high expression correlates with better patient survival, revealing an anti-oncogenic role.

Keywords:
EGFRPLCE1RAS signaling pathwayRASGRF1VEGF

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