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EFFICACY OF ORAL VORICONAZOLE VERSUS ORAL ITRACONAZOLE, IN THE TREATMENT OF DERMATOPHYTE INFECTIONS
Maira Ali1, Najia Ahmed1, Seemab Khan1
1Department of Dermatology, PNS Shifa, Karachi-Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
|November 29, 2024
Summary
Voriconazole demonstrates superior efficacy in treating drug-resistant dermatophyte infections compared to itraconazole. This study highlights voriconazole as a promising alternative for challenging fungal skin conditions.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Dermatophyte infections are prevalent in humid, tropical climates.
- Increasing antifungal resistance necessitates novel treatment strategies.
- Voriconazole emerges as a promising therapeutic agent for resistant fungal infections.
Purpose of the Study:
- To compare the efficacy of voriconazole versus itraconazole in treating dermatophyte infections.
- To evaluate treatment outcomes in patients with resistant fungal skin conditions.
Main Methods:
- A study involving 76 patients divided into two groups: voriconazole (Group A) and itraconazole (Group B).
- Treatment duration varied based on response (2 weeks for complete, 4 weeks for partial).
- Comprehensive laboratory tests (CBC, LFTs, RFTs, blood sugar) and KOH microscopy were performed pre- and post-treatment.
Main Results:
- Voriconazole achieved complete lesion clearance in 84.2% of patients, with 15.8% showing partial response.
- Itraconazole resulted in only 15.7% complete response, 42.1% partial response, and 42.2% no improvement.
Conclusions:
- Voriconazole exhibits significantly better efficacy and outcomes for resistant dermatophyte infections.
- The findings support voriconazole as a preferred treatment option for challenging fungal infections.
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