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Factors predisposing to exercise-induced late asthmatic responses
The Journal of Allergy and Clinical Immunology
|February 1, 1985
Summary
Children with exercise-induced asthma who experience dual reactions, both early and late asthmatic responses, show a slower recovery from early reactions. This slower recovery may predict the development of late-phase reactions in asthma.
Area of Science:
- Pediatric Pulmonology
- Exercise-Induced Asthma Research
- Respiratory Medicine
Background:
- Exercise can trigger asthma symptoms in children, sometimes leading to dual asthmatic responses (early and late reactions).
- Understanding the factors predicting late-phase reactions is crucial for managing exercise-induced asthma.
Purpose of the Study:
- To investigate the relationship between early and late asthmatic responses in children after exercise.
- To determine if disease severity or baseline airway reactivity influences the development of late asthmatic reactions.
- To identify predictors for late-phase reactions in exercise-induced asthma.
Main Methods:
- Seventeen children with exercise-induced asthma underwent cycle ergometer testing to assess early and late asthmatic responses.
- Comparison of clinical severity, diurnal FEV1 variation, and acetylcholine responsiveness between children with dual and single asthmatic responses.
- Analysis of the rate of spontaneous recovery from early asthmatic reactions.
Main Results:
- A significant correlation was found between the magnitude of early and late asthmatic responses.
- No significant differences in asthma severity or baseline airway reactivity were observed between children with dual and single responses.
- Children with dual responses exhibited a slower spontaneous recovery rate from early asthmatic reactions compared to those with single responses.
Conclusions:
- The development of late asthmatic reactions after exercise is not solely determined by asthma severity or baseline airway hyperresponsiveness.
- Slower spontaneous recovery from early asthmatic reactions may serve as a predictor for the subsequent development of late-phase reactions in exercise-induced asthma.
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