Improving Enamel Acid Resistance by an Intraoral Fluoride-Release Device Incorporating Cationic Hydroxy Cellulose Gel...

Area of Science:

• Biomaterials Science
• Dental Research
• Preventive Dentistry

Background:

• Intraoral fluoride-releasing devices (IFRDs) provide prolonged, low-concentration fluoride uptake for enhanced dental health.
• Traditional IFRDs can be improved with advanced materials for better fluoride delivery.

Purpose of the Study:

• To develop and evaluate a novel 3D-printed intraoral fluoride-releasing device (IFRD) utilizing a new cationic slow-release fluoride gel.
• To compare the efficacy of a cationic fluoride gel against a non-cationic gel in improving enamel acid resistance in vitro.

Main Methods:

• Synthesized hydroxyethyl cellulose-based gels: non-cationic (SE600) and cationic (L200).
• Developed a 3D additive manufactured IFRD for fluoride gel delivery.
• Assessed fluoride ion concentration release over 60 minutes.
• Evaluated enamel acid resistance of bovine teeth using polarized light microscopy, electron microscopy, and micro-radiography to measure tooth loss, mineral loss (ΔZ), and lesion depth (Ld).

Main Results:

• Cationization significantly increased fluoride ion concentration in the gel (SE600: 0.68 ± 0.08 ppm; L200: 4.24 ± 0.83 ppm after 60 min).
• The cationic L200 gel group demonstrated significantly reduced ΔZ and Ld compared to the SE600 group.
• Enhanced enamel acid resistance was observed with the cationic fluoride gel.

Conclusions:

• The novel 3D-printed IFRD with a cationic slow-release fluoride gel effectively enhances enamel acid resistance.
• This technology shows promise for improving oral care in settings with limited access to regular dental services.
• Potential applications include preventive dentistry, nursing homes, and dental clinic settings.