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Updated: May 7, 2025

High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds
Published on: August 18, 2023
New cytotoxic compounds from Viscum coloratum (Kom.) Nakai
Bo Wen1, Juan Pan1, Yu-Qing Wang1
1Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education + Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First-Class Construction Interdiscipline), Harbin, China.
Abstract:
Twenty-one compounds were isolated and identified from the ethanol extract of Viscum coloratum (Kom.) Nakai, including two new compounds (1 and 3), a new artificial product (2) and eighteen known compounds (4-21). Compounds 4-9 and 11-20 were isolated from Santalaceae for the first time. In this paper, compounds' structures identified by NMR spectroscopy and compare their data with those in the literature. Meanwhile, all compounds were assessed for cytotoxic activity against HepG2 cells, revealing that compound 1 exhibited significant cytotoxicity with IC50 value 6.70 ± 2.12 μM.

