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Updated: Jun 3, 2025

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
Oshadi Edirisinghe1, Gaëtane Ternier2, Zeina Alraawi2
1Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.
Fibroblast Growth Factors (FGFs) and Fibroblast Growth Factor Receptors (FGFRs) are key regulators of cell functions. Understanding their complex signaling is vital for developing therapies for FGF-related diseases.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are crucial for numerous biological processes.
- These include cell proliferation, differentiation, tissue repair, and metabolic homeostasis.
Purpose of the Study:
- To provide a comprehensive review of FGF-FGFR signaling pathways.
- To highlight their complex regulatory mechanisms and interconnections with other signaling networks.
- To discuss the roles of FGFs in development, metabolism, and housekeeping functions.
Main Methods:
- Literature review of existing research on FGF-FGFR signaling.
- Analysis of regulatory mechanisms and pathway interconnections.
- Synthesis of information on FGF functions in various biological contexts.
Main Results:
- FGF-FGFR signaling is a complex network with significant roles in fundamental biological processes.
- Interconnections with other signaling pathways add layers of regulatory complexity.
- FGFs are involved in critical developmental, metabolic, and cellular maintenance functions.
Conclusions:
- Enhanced understanding of FGF-FGFR signaling is essential for advancing therapeutic development.
- This knowledge is crucial for addressing FGF-related pathological conditions.
- Further research into these pathways will facilitate novel treatment strategies.
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