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Circadian Deregulation: Back Facing the Sun Toward Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
1Gastroenterology Department, Hospital de Vila Franca de Xira, 2600-009 Vila Franca de Xira, Portugal.
Nutrients
|January 8, 2025
Summary
Modern lifestyles disrupt natural circadian rhythms, leading to metabolic dysfunction and diseases like metabolic dysfunction-associated steatotic liver disease (MASLD) and cancer. Restoring circadian balance is crucial for metabolic health.
Area of Science:
- Chronobiology
- Metabolic Health
- Hepatology
Background:
- Humans evolved circadian rhythms aligned with Earth's 24-hour light-dark cycle, influencing metabolism and energy homeostasis.
- Modern lifestyle changes have led to widespread circadian disruption, impacting sleep and eating patterns.
- This misalignment is increasingly linked to metabolic disorders, including obesity, metabolic syndrome, and metabolic dysfunction-associated steatotic liver disease (MASLD).
Purpose of the Study:
- To review the impact of circadian disruption on metabolism.
- To explore the specific roles of disrupted feeding and sleep cycles in the pathogenesis of MASLD.
- To examine the connection between circadian disruption, MASLD, and the development of hepatocellular carcinoma.
Main Methods:
- Literature review focusing on chronobiology, metabolism, and liver disease.
- Analysis of studies investigating the effects of sleep and feeding schedule alterations on metabolic homeostasis.
- Synthesis of evidence linking circadian disruption to MASLD and hepatocellular carcinoma development.
Main Results:
- Circadian misalignment significantly alters metabolic processes and energy balance.
- Disrupted circadian rhythms promote conditions favoring fat accumulation in the liver, leading to MASLD.
- Evidence suggests a correlation between circadian disruption, MASLD, and an increased risk of hepatocellular carcinoma.
Conclusions:
- Circadian disruption is a significant environmental factor contributing to metabolic diseases like MASLD.
- Understanding the interplay between circadian rhythms, diet, sleep, and liver health is critical for disease prevention and treatment.
- Further research into chrononutrition and chronotherapy may offer novel strategies for managing MASLD and reducing cancer risk.
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