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Phagocyte functions in familial Mediterranean fever
Advances in Experimental Medicine and Biology
|January 1, 1979
Summary
Patients with familial Mediterranean fever (F.M.F.) exhibit reduced monocyte phagocytosis and bacterial killing. Their neutrophils show increased movement, which colchicine treatment can reduce.
Area of Science:
- Immunology
- Hematology
- Infectious Diseases
Background:
- Familial Mediterranean fever (F.M.F.) is an autoinflammatory disorder.
- Immune cell function may be altered in F.M.F. patients.
Purpose of the Study:
- To investigate monocyte and neutrophil functions in F.M.F. patients.
- To assess the impact of colchicine on these immune cell functions.
Main Methods:
- Monocyte phagocytosis assay using Shigella flexneri.
- Bactericidal activity assay against S. albus.
- Neutrophil (PMN) chemokinesis and chemotaxis assays.
Main Results:
- F.M.F. monocytes showed decreased phagocytic and bactericidal capacity compared to controls.
- Neutrophil chemokinesis was enhanced in F.M.F. patients, particularly during attacks.
- Colchicine did not affect monocyte functions but reduced neutrophil chemotaxis.
Conclusions:
- F.M.F. is associated with impaired monocyte function and altered neutrophil migration.
- Colchicine may modulate neutrophil behavior in F.M.F. patients.