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The Relationship Between ADAMTS-4 and ADAMTS-5 Enzyme Levels in Patients With Degenerative Disc Disease: A

Cansu Tuncer1, Emin Mehmet Eminoğlu2, Ömer Emre Yağlı3

  • 1Department of Neurosurgery, Sorgun State Hospital Yozgat Turkey.

JOR Spine
|January 9, 2025
PubMed
Summary

Levels of A Disintegrin and Metalloproteinase with Thrombospondin motifs-4 (ADAMTS-4) were lower, while A Disintegrin and Metalloproteinase with Thrombospondin motifs 5 (ADAMTS-5) were higher in patients with intervertebral disc disease compared to controls. Elevated ADAMTS-5 may indicate disc degeneration.

Keywords:
ADAMTS‐4ADAMTS‐5biomarkerslumbar disc degeneration

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