Marine-Derived Compound Targeting mTOR and FGFR-2: A Promising Strategy for Breast, Lung, and Colorectal Cancer...

Area of Science:

• Marine biotechnology
• Drug discovery
• Computational chemistry

Background:

• Marine environments are rich sources of bioactive compounds with medicinal properties.
• Pharmaceutical research increasingly focuses on marine-derived natural products.

Purpose of the Study:

• To investigate the anticancer potential of marine bioactive compounds.
• To identify marine compounds that inhibit cancer-specific target proteins.

Main Methods:

• Gas Chromatography-Mass Spectrometry (GC-MS) for compound identification.
• Molecular docking simulations against cancer-associated proteins (mTOR, FGFR2).

Main Results:

• 1,4:3,6:5,7-Tribenzal-beta-mannoheptitol demonstrated inhibitory activity against mTOR (PDB ID: 4JSV) and FGFR2 (PDB ID: 6V6Q).
• Docking simulations proved effective in identifying potential therapeutic agents.

Conclusions:

• Marine-derived compounds, like 1,4:3,6:5,7-Tribenzal-beta-mannoheptitol, show significant potential for cancer drug development.
• Further research into these compounds could lead to novel cancer therapeutics.