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3D Quantitative MRI: A Fast and Reliable Method for Ventricular Volumetry.
Rafael T Holmgren1, Anders Tisell2, Marcel J B Warntjes3
1Departments of Neurosurgery, Biomedical and Clinical Sciences, Linköping University, Sweden.
World Neurosurgery
|January 9, 2025
Summary
Quantitative MRI (qMRI) offers reliable and efficient 3D ventricular volumetry for assessing cerebrospinal fluid spaces. Manually corrected automatic segmentations are feasible for clinical use in idiopathic normal pressure hydrocephalus (iNPH) patients.
Area of Science:
- Neuroimaging
- Radiology
- Medical Physics
Background:
- Cerebral ventricle volumetry is crucial for assessing conditions like idiopathic normal pressure hydrocephalus (iNPH).
- Traditional 2D measures are less sensitive than volumetric analysis.
- Current ventricle segmentation methods are time-consuming, limiting clinical application.
Purpose of the Study:
- To evaluate the reliability and processing time of manual and manually corrected automatic ventricular volumetry using 3D quantitative MRI (qMRI).
- To assess the feasibility of 3D qMRI for clinical and research applications in cerebrospinal fluid space assessment.
Main Methods:
- 3D qMRI data from 45 participants (15 healthy, 15 iNPH, 15 shunted iNPH) were analyzed.
- Manual ventricular volumetry was performed twice by one examiner and once by another.
- Automatic segmentation was generated and subsequently manually corrected by both examiners.
- Intra- and interobserver reliability was assessed using intra-class correlation coefficients.
Main Results:
- Excellent intra- and interobserver reliability was observed for all segmentation methods (manual, corrected, automatic).
- Average ventricular volumes were 42 ± 18 mL (healthy), 140 ± 34 mL (iNPH), and 113 ± 35 mL (shunted iNPH).
Conclusions:
- 3D qMRI provides a reliable and time-efficient method for volumetric assessment of intracranial cerebrospinal fluid spaces.
- Manually corrected automatic segmentations offer a feasible processing time for clinicians managing iNPH patients.
