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Updated: Jun 3, 2025

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
Published on: February 3, 2018
Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS: A comparative study with single
Benjamin T Manard1, Veronica C Bradley2, Lyndsey Hendriks3
1Chemical Sciences Division, Oak Ridge National Laboratory, USA.
Abstract:
Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO4) nanoparticles (∼120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R2 between 0.98 and 0.99) compared to ICP-TOF-MS (R2 between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the 142Nd/144Nd, 143Nd/144Nd, 145Nd/144Nd, 146Nd/144Nd, and 148Nd/144Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. When utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2 fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.
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