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Updated: May 6, 2026
09:01
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
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MFSD6 is an entry receptor for respiratory enterovirus D68
Xize Liu1, Huili Li1, Zhaoxue Li2
1Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Cell Host & Microbe
|January 11, 2025
Summary
Researchers identified major facilitator superfamily-domain-containing protein 6 (MFSD6) as a key factor for Enterovirus D68 (EV-D68) entry. A novel therapeutic agent targeting MFSD6 effectively blocked EV-D68 infection and protected mice.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Enterovirus D68 (EV-D68) causes severe respiratory and neurological illness in children.
- No approved antiviral therapies exist to inhibit EV-D68 infection.
- Viral entry mechanisms are critical targets for antiviral drug development.
Purpose of the Study:
- To identify host factors essential for EV-D68 entry.
- To investigate the role of MFSD6 in EV-D68 infection.
- To develop a potential therapeutic strategy targeting EV-D68 entry.
Main Methods:
- Identified MFSD6 as an EV-D68 entry factor through functional screening.
- Characterized MFSD6-EV-D68 interactions using binding assays.
- Engineered a recombinant MFSD6-Fc fusion protein (MFSD6-Fc(CH3)).
- Assessed the antiviral efficacy of MFSD6-Fc(CH3) in vitro and in vivo.
Main Results:
- MFSD6 is crucial for EV-D68 replication and virus attachment to host cells.
- The second extracellular domain of MFSD6 mediates EV-D68 recognition.
- MFSD6-Fc(CH3) potently inhibited EV-D68 entry and infection.
- MFSD6-Fc(CH3) protected newborn mice from lethal EV-D68 challenge.
Conclusions:
- MFSD6 is a novel host entry factor for EV-D68.
- MFSD6 represents a promising therapeutic target for EV-D68.
- MFSD6-Fc(CH3) demonstrates potential as an antiviral agent against EV-D68.
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