Development and In-Vitro Tuning of Piperine Containing Solid Lipid Microparticles for the Treatment of Rheumatoid
Muneeba Aziz1, Sajid Bashir1, Rai Muhammad Sarfraz2
1College of Pharmacy, University of Sargodha, Sargodha, Pakistan.
AAPS Pharmscitech
|January 22, 2025
Summary
This study developed piperine-loaded solid lipid microparticles (SLMs) to treat arthritis. The SLMs demonstrated sustained piperine release and significant anti-arthritic effects in rats, offering a promising new therapeutic approach.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Piperine (PIP) possesses anti-inflammatory properties but faces bioavailability challenges.
- Solid lipid microparticles (SLMs) offer a potential delivery system for enhancing drug efficacy.
Purpose of the Study:
- To develop piperine-loaded solid lipid microparticles (SLMs) for assessing the anti-arthritic potential of piperine.
- To characterize the physicochemical properties and in vitro/in vivo performance of the developed SLMs.
Main Methods:
- SLMs were prepared using carnauba wax, beeswax, and tween 80 via solvent evaporation.
- Characterization included particle size, entrapment efficiency, zeta potential, FTIR, XRD, DSC, TGA, SEM, and in vitro dissolution studies.
- Anti-rheumatic activity was evaluated in a rat model compared to diclofenac sodium.
Main Results:
- SLMs exhibited sustained piperine release (87.82%–94.92% over 24 h at pH 7.4) following zero-order and Korsmeyer-Peppas kinetics.
- FTIR, XRD, DSC, and TGA confirmed piperine-lipid compatibility and thermal stability.
- SEM revealed a porous surface morphology.
- Piperine-loaded SLMs significantly reduced arthritis severity in rats.
Conclusions:
- Piperine-loaded SLMs are a viable formulation for sustained drug delivery.
- The developed SLMs demonstrate significant anti-arthritic potential, comparable to standard treatments.
- This formulation offers a promising strategy for managing arthritis through enhanced piperine delivery.
Keywords:
Carnauba wax and bees waxMicroparticlesPiperinePiperine-loaded microparticlesRheumatoid arthritisMore Related Videos
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