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Biases in Volumetric Versus Surface Analyses in Population Receptive Field Mapping.

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  • 1High Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

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|January 24, 2025
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Summary

Upsampling functional MRI (fMRI) data for population receptive field (pRF) mapping can bias results, particularly in early visual cortex (V1-3). This bias, driven by cortical magnification, affects central visual field coverage and impacts cross-study comparisons.

Keywords:
cortical magnificationfMRIpRF mappingretinotopyvisual cortex

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Area of Science:

  • Neuroimaging
  • Computational Neuroscience
  • Visual Neuroscience

Background:

  • Population receptive field (pRF) mapping is a key functional MRI (fMRI) technique.
  • fMRI data is often projected onto the cortical surface, involving upsampling.
  • This preprocessing step may introduce biases in pRF parameter estimation.

Purpose of the Study:

  • To investigate biases introduced by upsampling fMRI data in pRF analysis.
  • To compare pRF maps derived from volumetric versus upsampled surface data.
  • To understand the impact of cortical magnification on pRF mapping.

Main Methods:

  • Utilized publicly available analysis containers for fMRI data processing.
  • Compared pRF maps generated from original volumetric data and upsampled surface data.
  • Analyzed early visual cortex areas V1-3.

Main Results:

  • Upsampled surface data showed substantial increases in pRF coverage in the central visual field.
  • These effects were consistent across visual areas V1-3.
  • The bias was primarily attributed to cortical magnification, a nonlinear relationship between cortical distance and visual field eccentricity.

Conclusions:

  • Upsampling fMRI data for pRF mapping introduces significant biases, particularly affecting central visual field representation.
  • Cortical magnification is a key driver of these observed biases.
  • Understanding and mitigating these processing-induced biases are crucial for accurate interpretation of pRF mapping studies and cross-study comparisons.