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Updated: May 31, 2025
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Cyclodextrins and their applications in pharmaceutical and related fields
Adeela Khurshid1, Zubair Anwar1, Aqeela Khurshid1
1Department of Pharmaceutics, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
Profiles of Drug Substances, Excipients, and Related Methodology
|January 24, 2025
Summary
Cyclodextrins (CDs) are versatile macromolecules that enhance drug properties like solubility and stability by forming inclusion complexes. Their pharmaceutical applications extend to drug delivery, safety, and formulation across various dosage forms.
Area of Science:
- Macromolecular science and pharmaceutical chemistry.
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with unique cage-like structures.
- They possess the ability to form inclusion complexes with a wide range of guest molecules.
Purpose of the Study:
- To provide a comprehensive overview of cyclodextrins (CDs).
- To detail their classification, properties, and complexation techniques.
- To highlight their diverse pharmaceutical and other industrial applications.
Main Methods:
- Review of literature on cyclodextrin chemistry and applications.
- Description of techniques for forming cyclodextrin-drug inclusion complexes.
- Analysis of the impact of complexation on drug physicochemical properties.
Main Results:
- CD-drug inclusion complexes significantly improve drug solubility, stability (chemical and photochemical), and reduce toxicity.
- CDs enhance drug bioavailability, facilitate controlled drug delivery, and improve drug safety.
- CDs serve as effective excipients in solid, parenteral, and anticancer drug formulations.
Conclusions:
- Cyclodextrins are highly valuable in pharmaceutical formulations, improving drug efficacy and safety.
- Their applications extend beyond pharmaceuticals to cosmetics, environmental protection, food technology, and analytical chemistry.
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