Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Biotechnology

Background:

• Nanosuspensions (NS) utilize submicron particle technology to improve the delivery of poorly soluble drugs.
• Their unique physicochemical properties offer versatile solutions for various administration routes.

Purpose of the Study:

• To review recent advancements, future prospects, and challenges in nanosuspension (NS)-based drug delivery.
• To explore preparation methods, characterization techniques, and commercial applications of NS.

Main Methods:

• Comprehensive literature review of NS formulations, stabilizers, and excipients.
• Analysis of in vitro/in vivo characterization, scale-down, and preparation technologies.
• Discussion of clinical trials, patents, and commercial NS products.

Main Results:

• NS formulations can be adapted into various dosage forms (powders, tablets, capsules, films) to enhance stability and delivery.
• Key stabilizers, polymers, and surfactants are crucial for NS formulation development.
• Advances in preparation and characterization support NS development for diverse routes.

Conclusions:

• Nanosuspensions show significant promise for overcoming absorption limitations and hepatic first-pass metabolism, especially for protein and peptide drugs.
• Novel stabilizers are essential for improving NS stability, bioavailability, targeting, and safety.
• Continued innovation in NS technology will accelerate clinical application and commercialization.