Dual physiological responsive structural color hydrogel particles for wound repair

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Intelligent hydrogel dressings show promise for diabetic wound repair.
• Continuous monitoring and repair promotion are key capabilities for advanced wound care.

Purpose of the Study:

• To develop dual physiological responsive structural color particles for enhanced diabetic wound repair.
• To create a smart wound dressing with integrated monitoring and therapeutic release functionalities.

Main Methods:

• Fabrication of dual-network hydrogel particles using hyaluronic acid methacryloyl (HAMA)-sodium alginate (Alg) scaffold.
• Incorporation of oxidized dextran (ODex)/quaternized chitosan (QCS) hydrogel with glucose oxidase (GOX), antimicrobial peptide (AMP), and vascular endothelial growth factor (VEGF).
• Evaluation of pH/glucose dual responsiveness and structural color change for wound monitoring and therapeutic release.

Main Results:

• The HAMA-Alg scaffold formed a stable dual-network hydrogel with inherent structural color.
• The ODex/QCS hydrogel demonstrated pH/glucose dual responsiveness, triggered by glucose oxidase activity.
• Controlled release of AMP and VEGF in response to high glucose levels, promoting diabetic wound healing in vivo.
• Structural color changes in the particles provided a visual indicator for wound status.

Conclusions:

• The developed dual responsive particles show significant potential for effective diabetic wound repair.
• The integrated monitoring and therapeutic release system offers a novel approach for advanced wound management.
• These smart hydrogel particles could be valuable in treating diabetic wounds and related conditions.